Related Experiment Video
Updated: Jul 16, 2025

The Unpredictable Chronic Mild Stress Protocol for Inducing Anhedonia in Mice
Published on: October 24, 2018
Resveratrol and 2-Ethyl-6-Methyl-3-Hydroxypiridine N-Acetyl Cysteinate as Protecting Agents upon the Stress Exposure
Irina V Zhigacheva1, Irina F Rusina2, Natalia I Krikunova1
1Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Ul. Kosygina 4, Moscow 119334, Russia.
Abstract:
The increased generation of reactive oxygen species (ROS) by mitochondria under stress conditions leads to lipid peroxidation (LPO) as a consequence of the ROS interactions with polyunsaturated fatty acids in the lipid bilayer of cell membranes, causing their damage. It was assumed that chemical preparations that reduce the excessive ROS generation by mitochondria should exhibit protecting properties under oxidative-stress conditions. In this context, the antioxidants resveratrol (RSV) and 2-ethyl-6-methyl-3-hydroxypyridine N-acetylcysteinate (NAC-3-HP) were examined as potential chemical protectors upon the exposure to stress, able to maintain the functional state of mitochondria.
Related Concept Videos
Stress Response System
Alarm stage
In the alarm stage, the body's...
Stress Prevention and Stress Management Techniques IV
Physiological Foundation of Stress
Role of the Sympathetic Nervous System
Adrenaline triggers the...
Stress Prevention and Stress Management Techniques VI
Motivation and Self-Determination
Motivation, the driving force behind behavior, plays a pivotal role at every stage of the change process. The research...
Introduction to Stress and Lifestyle
Psychological Responses to Stress

