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Transferrin-Targeted Liposomes in Glioblastoma Therapy: A Review.

Paul Kawak¹, Nour M Al Sawaftah², William G Pitt³

¹Chemical and Biological Engineering Department, College of Engineering, American University of Sharjah, Sharjah P.O. Box 26666, United Arab Emirates.

International Journal of Molecular Sciences

|September 9, 2023

Summary

Transferrin-conjugated liposomes show promise for glioblastoma (GBM) treatment by overcoming the blood-brain barrier. This review explores their potential, challenges, and improvements for effective brain tumor therapy.

Keywords:

blood-brain barrier cancer glioblastoma liposomes targeted drug delivery transferrin

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Area of Science:

Oncology
Nanotechnology
Pharmacology

Background:

Glioblastoma (GBM) is an aggressive brain tumor with limited treatment options due to the blood-brain barrier (BBB).
Conventional chemotherapy faces challenges like poor bioavailability and systemic toxicity.
Passive liposome targeting lacks specificity for brain tissue.

Purpose of the Study:

To review the role of transferrin (Tf)-conjugated liposomes in glioblastoma therapy.
To evaluate the drug delivery efficiency of Tf-liposomes for brain tumors.
To discuss current challenges and potential improvements in Tf-liposome-based GBM treatment.

Main Methods:

Review of existing literature on Tf-conjugated liposomes for GBM.
Analysis of studies investigating Tf-liposome drug delivery efficiency.
Discussion of active targeting strategies utilizing transferrin receptors (TfRs).

Main Results:

Tf-conjugated liposomes offer active targeting by exploiting upregulated TfRs in brain tissue.
These liposomes demonstrate potential for enhanced drug delivery across the BBB.
Recent studies show promising, yet variable, drug delivery efficiencies.

Conclusions:

Tf-conjugated liposomes represent a promising strategy for targeted glioblastoma therapy.
Further research is needed to overcome current challenges and optimize drug delivery.
Active targeting via TfRs holds significant potential for improving GBM treatment outcomes.