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Advances in Research on Type 2 Diabetes Mellitus Targets and Therapeutic Agents

Jingqian Su1,2,3, Yingsheng Luo1,2,3, Shan Hu1,2,3

  • 1Fujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, Fujian Normal University, Fuzhou 350117, China.

International Journal of Molecular Sciences
|September 9, 2023
PubMed

Insights

Type 2 diabetes mellitus (T2DM) requires new treatments as single-target drugs are insufficient. This review explores novel therapeutic targets and agents for improved glycemic control in T2DM management.

Area of Science:

  • Endocrinology
  • Pharmacology
  • Metabolic Diseases

Background:

  • Type 2 diabetes mellitus (T2DM) is a chronic, complex condition with significant morbidity and mortality, projected to be the seventh leading cause of death by 2030.
  • Current antidiabetic medications, including GLP-1 receptor agonists and SGLT-2 inhibitors, face limitations due to individual variability and disease complexity.
  • The need for advanced therapeutic strategies is critical to overcome resistance and improve glycemic control in T2DM patients.

Purpose of the Study:

  • To provide a comprehensive overview of recent advancements in T2DM therapeutic agents.
  • To discuss emerging target-based therapies and novel therapeutic targets identified in the last three years.
  • To establish a theoretical foundation for future targeted T2DM therapies.

Main Methods:

  • Literature review of recent scientific publications on T2DM pathogenesis and treatment.
  • Analysis of mechanisms of action for current and emerging antidiabetic drugs.
  • Identification and discussion of novel therapeutic targets and strategies.

Main Results:

  • Overview of established and novel therapeutic agents for T2DM.
  • Discussion of the limitations of single-target therapies in managing T2DM.
  • Identification of emerging therapeutic targets and strategies for T2DM treatment.

Conclusions:

  • Single-target therapies are increasingly inadequate for T2DM management.
  • Further research into T2DM pathogenesis is essential for identifying multiple therapeutic targets.
  • This review offers a basis for developing more effective, targeted T2DM therapies.
Keywords:
mechanismmedicinetargettype 2 diabetes mellitus

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