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Meta-Analysis of Heat-Stressed Transcriptomes Using the Public Gene Expression Database from Human and Mouse Samples
Sora Yonezawa1, Hidemasa Bono1,2
1Laboratory of Genome Informatics, Graduate School of Integrated Sciences for Life, Hiroshima University, 3-10-23 Kagamiyama, Higashi-Hiroshima City 739-0046, Japan.
International Journal of Molecular Sciences
|September 9, 2023
Summary
Climate change intensifies heat exposure, impacting health. This study identified key heat stress-responsive genes common in humans and mice, including previously overlooked ones, aiding adaptation strategies.
Area of Science:
- Environmental Health
- Genomics
- Climate Change Adaptation
Background:
- Rising global temperatures due to climate change increase the frequency and severity of heat exposure.
- Heat stress poses significant risks to human health and various industries.
- Understanding the genetic mechanisms of heat stress response is crucial for developing mitigation strategies.
Approach:
- A meta-analysis of human and mouse gene expression datasets was performed to identify heat stress-responsive genes.
- Identified 76 upregulated and 37 downregulated genes common to both species.
- Integrated analyses included gene enrichment, protein-protein interaction networks, transcription factor targets, and ChIP-seq data for HSF1, HSF2, and PGC-1α.
Key Points:
- Identified 76 upregulated and 37 downregulated genes commonly responsive to heat stress in humans and mice.
- Highlighted previously under-represented genes like ABHD3, ZFAND2A, and USPL1 as significantly upregulated.
- Revealed insights into the genetic regulatory networks governing heat stress responses.
Conclusions:
- The identified common heat stress-responsive genes provide a foundation for understanding organismal adaptation to high temperatures.
- Further functional analysis of these genes, particularly novel ones, can inform strategies to mitigate the adverse effects of climate change.
- This research contributes to developing technological advancements for heat stress resilience.
