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Updated: Jul 16, 2025

Combined Intravital Microscopy and Contrast-enhanced Ultrasonography of the Mouse Hindlimb to Study Insulin-induced Vasodilation and Muscle Perfusion
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Published on: March 20, 2017

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Improvement of Vascular Insulin Sensitivity by Ranolazine

Sol Guerra-Ojeda1, Adrian Jorda1,2, Constanza Aldasoro1

  • 1Department of Physiology, University of Valencia, 46010 València, Spain.

International Journal of Molecular Sciences
|September 9, 2023
PubMed

Insights

Ranolazine enhances insulin

Area of Science:

  • Pharmacology
  • Cardiovascular Physiology
  • Endocrinology

Background:

  • Ranolazine (RN) treats chronic coronary ischemia.
  • Clinical trials suggest RN has anti-diabetic properties, lowering blood glucose and HbA1c.
  • RN's effect on insulin sensitivity remains unclear.

Purpose of the Study:

  • To investigate Ranolazine's potential to facilitate insulin's actions in the rabbit aorta.
  • To understand the mechanisms behind RN's interaction with insulin signaling pathways.

Main Methods:

  • Studied insulin-induced vasodilation and its relation to eNOS phosphorylation and NO formation.
  • Examined RN's effect on insulin's vasodilator and vasoconstrictor modulation.
  • Assessed the impact of combined RN and insulin on p-eNOS/eNOS and pAKT/AKT ratios.

Main Results:

  • Insulin induced concentration-dependent vasodilation via eNOS phosphorylation and NO.
  • RN potentiated all vasodilatory effects of insulin.
  • RN facilitated insulin's ability to decrease adrenergic vasoconstriction.
  • Combined RN and insulin significantly increased p-eNOS/eNOS and pAKT/AKT.

Conclusions:

  • Ranolazine enhances both direct and indirect vasodilator effects of insulin.
  • RN increases vascular sensitivity to insulin by reducing tissue resistance.
  • This mechanism is crucial for understanding and potentially treating type II diabetes.
Keywords:
adrenergic systeminsulinnitric oxideranolazinevascular

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