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Parenteral Nutrition in the Pediatric Oncologic Population: Are There Any Sex Differences?

Laura De Nardi1, Mariavittoria Sala1, Federico Turoldo1

  • 1Department of Medicine, Surgery and Health Sciences, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy.

Nutrients
|September 9, 2023
PubMed

Insights

Pediatric patients receiving total parenteral nutrition (TPN) show sex-based differences in nutrient needs and complications. Males experienced more hypertriglyceridemia and cholestasis, while females required higher phosphate intake.

Area of Science:

  • Pediatric Medicine
  • Nutritional Science
  • Gender-based Medicine

Background:

  • Gender-based medicine is gaining traction, but pediatric research, especially on sex differences in total parenteral nutrition (TPN), remains limited.
  • Understanding these differences is crucial for optimizing nutritional support in children.

Purpose of the Study:

  • To investigate sex-based differences in TPN composition and clinical outcomes in pediatric patients.
  • To establish a foundation for future gender-specific nutritional guidelines in pediatric care.

Main Methods:

  • Retrospective analysis of 145 pediatric patients (87 males, 58 females) receiving TPN.
  • Data collected included patient demographics, TPN details, nutrient composition, and clinical outcomes like metabolic alterations, liver damage, sepsis, and thrombosis.

Main Results:

  • Females required higher daily phosphate intake and essential amino acid supplementation.
  • Males exhibited a higher incidence of hypertriglyceridemia and cholestasis.
  • Non-transplanted males had a greater incidence of sepsis.

Conclusions:

  • Significant sex differences exist in TPN composition and outcomes among pediatric patients.
  • These findings highlight the need for tailored, gender-based nutritional strategies in pediatric TPN.
  • Further research is warranted to refine these gender-specific recommendations.

Keywords:
gender differenceshematological malignanciespediatric patientssex disparitiestotal parenteral nutrition

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