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Spice-Derived Phenolic Compounds: Potential for Skin Cancer Prevention and Therapy

Janette Baloghová1, Radka Michalková2, Zuzana Baranová1

  • 1Department of Dermatovenerology, Faculty of Medicine, Pavol Jozef Šafárik University, 040 01 Košice, Slovakia.

Molecules (Basel, Switzerland)
|September 9, 2023
PubMed

Insights

This review explores how spice-derived phenolic compounds may offer safer, effective prevention and treatment for skin cancers. Further research into these natural compounds could reveal new anticancer phytochemicals and strategies.

Area of Science:

  • * Phytochemistry
  • * Oncology
  • * Natural Product Chemistry

Background:

  • * Skin cancer, including melanoma, basal cell carcinoma, and squamous cell carcinoma, is primarily caused by ultraviolet (UV) radiation.
  • * Current targeted therapies for skin cancer require complementary safer and more effective prevention and treatment strategies.
  • * Spices, beyond culinary uses, contain bioactive phenolic compounds with significant biological effects, including potential anticancer properties.

Purpose of the Study:

  • * To review the potential of spice-derived phenolic compounds in preventing and treating skin cancers.
  • * To consolidate existing knowledge on these natural compounds for skin cancer management.
  • * To guide future research in identifying novel anticancer phytochemicals from spices.

Main Methods:

  • * Comprehensive literature review of scientific studies on spices, phenolic compounds, and skin cancer.
  • * Analysis of existing data on the biological activities and mechanisms of spice-derived phytochemicals.
  • * Synthesis of information regarding the preventive and therapeutic potential of these compounds.

Main Results:

  • * Spices contain diverse phenolic compounds with demonstrated antioxidant, anti-inflammatory, and antiproliferative activities.
  • * Preclinical studies suggest certain spice compounds can inhibit skin cancer cell growth and induce apoptosis.
  • * Phenolic compounds from spices show promise as chemopreventive and therapeutic agents against skin malignancies.

Conclusions:

  • * Spice-derived phenolic compounds represent a promising area for developing novel, natural agents for skin cancer prevention and treatment.
  • * Further investigation into specific phytochemicals and their mechanisms of action is warranted.
  • * This review highlights the potential of integrating natural compounds into broader skin cancer management strategies.
Keywords:
anticancer effectmelanomanon-melanoma skin cancerphenolic compoundsspice

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