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Optimizing the Growth of Endothiapepsin Crystals for Serial Crystallography Experiments
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Crystallization Selectivity of Ribavirin Solution and Amorphous Phase.

Fuying Li1,2, Shiying Chen1, Haoxin Hu3

  • 1Fujian Provincial Key Laboratory of Resources and Environment Monitoring & Sustainable Management and Utilization, Sanming University, Sanming 365004, China.

Molecules (Basel, Switzerland)
|September 9, 2023
PubMed
Summary
This summary is machine-generated.

This study explores crystallization selectivity in ribavirin polymorph control. Understanding short-range order in solid forms and solutions aids in developing robust methods for synthesizing metastable phases.

Keywords:
amorphous phasecrystallization selectivitymid-frequency Raman difference spectraribavirinsolutionsolvate

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Area of Science:

  • Solid-state chemistry
  • Crystallization science
  • Pharmaceutical polymorphs

Background:

  • Polymorph control is crucial in pharmaceutical development.
  • Ribavirin exhibits multiple solid forms, including Form I, Form II, a DMSO solvate, and amorphous states.
  • Understanding crystallization selectivity is key to controlling these polymorphs.

Purpose of the Study:

  • To investigate crystallization selectivity in ribavirin solid form preparation.
  • To compare the short-range order of different ribavirin solid forms with their solutions.
  • To explain crystallization processes and the challenges in preparing specific solvates.

Main Methods:

  • Preparation of Ribavirin Form I, Form II, DMSO solvate, and amorphous ribavirin.
  • Utilizing mid-frequency Raman difference spectra (MFRDS) to analyze short-range order.
  • Comparing spectral data of solid forms with aqueous and DMSO solutions of ribavirin.

Main Results:

  • Similarities in short-range order were identified between solid forms and their respective solutions.
  • The crystallization pathway from amorphous ribavirin to Form I was elucidated.
  • The transition from solution to an amorphous phase was explained.
  • Potential reasons for the difficulty in preparing the ribavirin DMSO solvate were proposed.

Conclusions:

  • The study provides a rationale for crystallization selectivity in ribavirin.
  • This understanding forms a basis for robust and convenient synthesis of metastable pharmaceutical phases.
  • The findings contribute to the broader field of polymorph control and solid-state chemistry.