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Related Concept Videos

Phases of Wound Repair01:28

Phases of Wound Repair

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Related Experiment Video

Updated: Jul 16, 2025

Digital Planimetry for Assessing Wound Closure Kinetics in a Mouse Model
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Modern Approaches in Wounds Management.

Simona-Maria Tatarusanu1,2, Florentina-Geanina Lupascu1, Bianca-Stefania Profire3

  • 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy "Grigore T. Popa" of Iasi, 16 Universitatii Street, 700115 Iasi, Romania.

Polymers
|September 9, 2023
PubMed
Summary

Smart hydrogels offer advanced wound healing by responding to external stimuli for improved treatment. This review explores their potential, limitations, and manufacturing perspectives for chronic wound care.

Keywords:
biopolymerssmart hydrogelsstimuli-responsivewound healingwounds assessment tools

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Polymer Chemistry

Background:

  • Wound management is a global healthcare challenge, requiring effective diagnosis and treatment strategies.
  • The wound dressing market is rapidly evolving with innovative formulations like hydrogels.
  • Chronic wounds necessitate advanced therapeutic approaches beyond traditional methods.

Purpose of the Study:

  • To review the physiopathology and healing mechanisms of chronic wounds.
  • To discuss the rationale and benefits of using traditional and smart hydrogels in wound healing.
  • To explore current research, limitations, and industrial-scale manufacturing perspectives of smart hydrogels.

Main Methods:

  • Literature review of chronic wound healing mechanisms and therapeutic strategies.
  • Analysis of hydrogel properties and their application in wound care.
  • Discussion of smart hydrogel composition, stimuli-responsiveness, and manufacturing.

Main Results:

  • Smart hydrogels exhibit tunable properties in response to external stimuli, enhancing wound healing.
  • They offer advantages like controlled drug release, self-healing, and adaptability.
  • Both natural and synthetic polymers can be used to create stimuli-responsive hydrogels.

Conclusions:

  • Smart hydrogels represent a promising advancement in wound care, offering tailored therapeutic responses.
  • Further research and development are needed to overcome limitations in stimuli-responsiveness and manufacturing.
  • Optimizing smart hydrogel design and production is crucial for their widespread clinical adoption.