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Triglyceride glucose index and renal function decline in Han Chinese hypertensive patients

Hung-Chang Chen1,2, Yun-Hsuan Tsai1,2,3, Chin-Chou Huang2,4,5

  • 1Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan.

Journal of Clinical Hypertension (Greenwich, Conn.)
|September 9, 2023
PubMed

Insights

The triglyceride glucose (TyG) index is linked to a higher risk of kidney function decline in hypertensive patients. This study found that elevated TyG index independently predicts worsening estimated glomerular filtration rate (eGFR) in this population.

Area of Science:

  • Cardiology
  • Nephrology
  • Metabolic Syndrome

Background:

  • Elevated triglyceride glucose (TyG) index is a known risk factor for cardiovascular disease.
  • Hypertension is a major contributor to chronic kidney disease and renal function decline.
  • The relationship between the TyG index and renal function decline in hypertensive patients requires further investigation.

Purpose of the Study:

  • To investigate the association between the triglyceride glucose (TyG) index and renal function decline in patients with essential hypertension.
  • To determine if the TyG index is an independent predictor of renal events in this cohort.

Main Methods:

  • A cohort of 548 Han Chinese patients with essential hypertension was studied.
  • The triglyceride glucose (TyG) index was calculated using fasting triglyceride and glucose levels.
  • Renal function decline was defined as a >25% decrease in estimated glomerular filtration rate (eGFR).
  • Cox proportional hazard regression models were employed to assess the independent effect of the TyG index on renal events.

Main Results:

  • During a mean follow-up of 4.7 years, 97 patients experienced a >25% decline in eGFR.
  • Patients with eGFR decline exhibited significantly higher fasting triglyceride, fasting glucose, and TyG index levels.
  • The TyG index (HR=1.490, P=0.041) was identified as an independent predictor of renal events, alongside office systolic blood pressure, diabetes mellitus, and baseline eGFR.

Conclusions:

  • An elevated triglyceride glucose (TyG) index is independently associated with an increased risk of estimated glomerular filtration rate (eGFR) decline in patients with hypertension.
  • The TyG index may serve as a valuable biomarker for predicting renal function deterioration in hypertensive individuals.

Keywords:
hypertensionnephropathyrenal functiontriglyceride glucose index

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