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Updated: Jul 16, 2025
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Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging
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Urinary Peptidomics and Pulse Wave Velocity: The African-PREDICT Study
Dalene de Beer1, Catharina Mc Mels1,2, Aletta E Schutte1,2,3
1Hypertension in Africa Research Team (HART),North-West University (Potchefstroom Campus), Potchefstroom 2531, South Africa.
Journal of Proteome Research
|September 9, 2023
Summary
Urinary collagen type I peptides are linked to increased arterial stiffness in young adults. This finding suggests collagen dysregulation may contribute to early vascular aging and cardiovascular disease risk.
Area of Science:
- Cardiovascular research
- Proteomics
- Vascular aging
Background:
- Increased arterial stiffness is a marker of early vascular aging and a predictor of cardiovascular disease.
- The molecular mechanisms, particularly at the proteome level, underlying arterial stiffness are not well understood.
Purpose of the Study:
- To investigate the association between pulse wave velocity, a measure of arterial stiffness, and urinary proteomics.
- To explore potential proteomic markers related to early vascular aging.
Main Methods:
- Analysis of urinary proteome using capillary electrophoresis time-of-flight mass spectrometry in 919 healthy young adults (20-30 years).
- Measurement of carotid-femoral pulse wave velocity to assess arterial stiffness.
- Statistical analysis, including multivariable adjusted models, to identify independent associations.
Main Results:
- Pulse wave velocity positively correlated with several collagen-derived peptides (types I, II, III, IV, V, IX) and inversely with collagen type XI.
- Positive correlations were observed with polymeric immunoglobulin receptor peptides.
- Multivariable analyses revealed independent associations between pulse wave velocity and seven urinary peptides, notably collagen type I-derived peptides.
Conclusions:
- Urinary collagen type I-derived peptides are significantly and independently associated with increased arterial stiffness.
- Dysregulation of collagen type I in the extracellular matrix may contribute to the early onset of arterial stiffness.
- Urinary proteomics may offer insights into the molecular pathways of vascular aging.
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