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Multi-organ phenotypes in mice lacking latent TGFβ binding protein 2 (LTBP2).

Nicholas K Bodmer^1,2, Russell H Knutsen², Robyn A Roth²

¹Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, USA.

Developmental Dynamics : an Official Publication of the American Association of Anatomists

|September 9, 2023

Summary

Mice lacking latent TGFβ-binding protein-2 (LTBP2) exhibit altered body weight, fat mass, bone, and skin development. These findings highlight LTBP2

Keywords:

LTBP2 LTBPs TGFβ fibroblasts myofibroblasts

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Area of Science:

Biochemistry
Developmental Biology
Extracellular Matrix Research

Background:

Latent TGFβ-binding protein-2 (LTBP2) is a microfibril component that binds fibrillin-1.
Unlike other LTBP proteins, LTBP2 does not bind TGFβ isoforms but may influence other LTBP functions or signaling pathways.

Purpose of the Study:

To investigate the developmental and homeostatic roles of LTBP2.
To identify phenotypes associated with the absence of LTBP2 in mice.

Main Methods:

Generation and analysis of mice lacking Ltbp2 (Ltbp2^-/-).
Phenotypic assessment of body weight, fat mass, bone development, and skin development.

Main Results:

Ltbp2^-/- mice display significant alterations in body weight, fat mass, bone, and skin development.
The strength of skin and bone tissues is differentially impacted by the loss of Ltbp2.
Tissues with high Ltbp2 expression, like the aorta and lung, showed no developmental or homeostatic phenotype.

Conclusions:

LTBP2 plays a complex role in development, potentially through direct extracellular matrix (ECM) modulation or interaction with ECM-regulating signaling pathways.
The absence of LTBP2 leads to specific tissue phenotypes, underscoring its importance in developmental processes.