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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Updated: Jul 16, 2025

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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Stem cell-based therapy for COVID-19.

Xiaomei Chen1, Bowen Liu1, Chao Li1

  • 1Department of Hematology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong 510080, PR China.

International Immunopharmacology
|September 9, 2023
PubMed
Summary

Stem cell therapies show promise for treating lung damage from COVID-19 and may serve as a novel vaccine. This review explores stem cell mechanisms, clinical trials, and engineered extracellular vesicles for COVID-19 prevention.

Keywords:
COVID-19Cell-based therapyClinical trialsExtracellular vesicleMesenchymal stem cellsVaccines

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Area of Science:

  • Immunology
  • Regenerative Medicine
  • Virology

Background:

  • COVID-19, despite no longer being a global health emergency, still poses risks due to reinfection and emerging variants.
  • Pulmonary complications from COVID-19 necessitate ongoing research into effective treatments and prevention strategies.

Purpose of the Study:

  • To systematically review stem cell-based therapies for COVID-19.
  • To explore the potential of engineered extracellular vesicles as a COVID-19 vaccine.
  • To summarize pathophysiological processes and mechanisms of stem cell therapy in COVID-19.

Main Methods:

  • Systematic review of existing literature.
  • Analysis of registered COVID-19 clinical trials involving stem cells.
  • Evaluation of preclinical and clinical data on stem cell derivatives and extracellular vesicles.

Main Results:

  • Stem cell derivatives demonstrate potential in preclinical and clinical studies for treating COVID-19-related pulmonary issues.
  • Engineered extracellular vesicles are being investigated as a novel vaccine approach for COVID-19 prevention.

Conclusions:

  • Stem cell-based approaches offer promising therapeutic avenues for COVID-19 lung injury.
  • Further research into extracellular vesicles could lead to innovative vaccine strategies against COVID-19.