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Microneedle-based cell delivery and cell sampling for biomedical applications.

Bricard Mbituyimana1, Manjila Adhikari1, Fuyu Qi1

  • 1Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|September 9, 2023
PubMed
Summary
This summary is machine-generated.

Microneedles (MNs) offer a minimally invasive method for cell delivery, overcoming barriers in cell-based therapies. This technology shows promise for treating incurable diseases and improving patient outcomes.

Keywords:
Biomedical applicationCell deliveryCell-based therapyLiving cellsMicroneedle

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Nanotechnology

Background:

  • Cell-based therapies hold potential for incurable diseases but face clinical translation challenges like poor delivery and safety.
  • Existing cell delivery methods often involve invasive procedures, limiting patient compliance and therapeutic efficacy.

Purpose of the Study:

  • To review advancements in microneedle (MN) technology for cell delivery and sampling.
  • To highlight the design, fabrication, and biomedical applications of MNs in cell therapy.
  • To discuss the clinical translation status and future perspectives of MN-based cell therapies.

Main Methods:

  • Review of recent literature on microneedle design, materials, and fabrication techniques for cell delivery.
  • Analysis of MN applications in tissue repair, cancer treatment, diabetes therapy, and cell sampling.
  • Examination of current clinical trial data and future challenges for MN-mediated cell therapies.

Main Results:

  • Microneedles provide a minimally invasive, pain-free, and convenient platform for enhanced cell delivery and sampling.
  • MNs have demonstrated efficacy in various applications, including wound healing, cardiac repair, and cancer treatment.
  • Significant progress has been made in MN design and fabrication, improving biosafety and biocompatibility.

Conclusions:

  • Microneedles represent a promising biomedical device for overcoming key barriers in cell-based therapeutics.
  • Further research and clinical translation are needed to fully realize the potential of MNs in regenerative medicine and disease treatment.
  • MN technology offers a simplified and effective approach to cell administration, potentially improving patient compliance and therapeutic success.