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Probing the molecular interactions between cholinium-based ionic liquids and insulin aspart: A combined computational

Vidya Sundaram1, Ramakrishnan Nagasundara Ramanan2, Manikandan Selvaraj3

  • 1Chemical Engineering Department, School of Engineering, Monash University Malaysia, Jalan Lagoon Selatan, 47500 Bandar Sunway, Selangor, Malaysia.

International Journal of Biological Macromolecules
|September 9, 2023
PubMed
Summary

Cholinium-based ionic liquids (ILs) stabilize insulin aspart (IA), with dihydrogen phosphate ([Dhp]-) showing stronger effects than acetate ([Ace]-). IL concentration is key to maintaining IA stability against water molecules.

Keywords:
Cholinium ionic liquidsCombinatorial approachInsulin aspartMolecular dynamics simulationsSpectroscopic analysisThermal stability

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