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Related Experiment Video

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Bronchoalveolar Lavage BAL for Research; Obtaining Adequate Sample Yield

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Unexpected Diffuse Alveolar Hemorrhage After Bronchoscopy.

Saya Tsukida¹, Satoshi Watanabe¹, Masato Hongo¹

¹Department of Respiratory Medicine, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan.

|September 9, 2023

Summary

A nonproductive cough in an elderly woman was linked to interstitial pneumonia. Elevated anti-Ro/SSA antibodies and lung imaging findings suggested Sjögren disease as the cause.

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Area of Science:

Rheumatology
Pulmonology
Immunology

Background:

Sjögren disease is a chronic autoimmune disorder primarily affecting exocrine glands.
Interstitial lung disease (ILD) is a known, albeit less common, manifestation of Sjögren disease.

Observation:

A 71-year-old woman presented with a nonproductive cough and dry mouth.
Autoantibody screening revealed elevated anti-Ro/SSA antibodies (240 U/mL) and positive antinuclear antibodies.
Chest CT showed bilateral lower lobe infiltrates.

Findings:

The clinical presentation and laboratory findings were consistent with interstitial pneumonia.
Elevated anti-Ro/SSA antibodies are a key indicator for Sjögren disease.
The infiltrative shadows on CT scan suggest early-stage lung involvement.

Implications:

This case highlights the importance of considering Sjögren disease in patients with unexplained interstitial pneumonia.
Early diagnosis and management of Sjögren disease-related ILD can potentially prevent disease progression.
Further investigation via fiber optic bronchoscopy with bronchoalveolar lavage is warranted for definitive diagnosis.