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Endospores are specialized, dormant cells primarily formed by Gram-positive bacteria, including Bacillus and Clostridium, enabling survival under extreme environmental conditions. Due to their unique composition and formation process, these structures are highly resistant to physical and chemical insults, such as extreme heat, ultraviolet and ionizing radiation, desiccation, and toxic chemicals. Rare instances of endospore-like structures have also been observed in some Gram-negative bacteria,...
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Updated: Jul 16, 2025

An In Vitro Dormancy Model of Estrogen-sensitive Breast Cancer in the Bone Marrow: A Tool for Molecular Mechanism Studies and Hypothesis Generation
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What is microbial dormancy?

Mark D McDonald1, Carlos Owusu-Ansah2, Jared B Ellenbogen3

  • 1Argonne National Laboratory, Environmental Sciences Division, Lemont, IL 60439, USA.

Trends in Microbiology
|September 9, 2023
PubMed
Summary
This summary is machine-generated.

Microbial dormancy, a state of reduced activity for survival, lacks a universal definition. This study proposes a unified definition and framework to contextualize existing ones and guide future research with multi-omics approaches.

Keywords:
environmental stressmicrobial dormancypermafrostpersistencesporulation

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Area of Science:

  • Microbiology
  • Molecular Biology
  • Environmental Science

Background:

  • Life faces stress, prompting survival strategies like microbial dormancy.
  • Dormancy involves reduced microbial activity and increased resistance.
  • Current definitions of microbial dormancy are discipline-specific.

Purpose of the Study:

  • To propose a unified definition of microbial dormancy.
  • To establish a broad framework for understanding dormancy across disciplines.
  • To explore the application of multi-omics tools for dormancy research.

Main Methods:

  • Literature review and synthesis of existing definitions.
  • Development of a conceptual framework for microbial dormancy.
  • Application of the framework to permafrost microbial communities.

Main Results:

  • A unified definition of microbial dormancy is proposed.
  • A framework is presented to contextualize discipline-specific definitions.
  • The framework aids in understanding dormancy mechanisms in extreme environments.

Conclusions:

  • A unified definition and framework enhance the study of microbial dormancy.
  • Multi-omics tools can be effectively applied within this new framework.
  • Understanding dormancy in extreme environments like permafrost is advanced.