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Measurement of Fatty Acid β-Oxidation in a Suspension of Freshly Isolated Mouse Hepatocytes
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Microbial modifications with Lycium barbarum L. oligosaccharides decrease hepatic fibrosis and mitochondrial

Zheng Zhang1, Wenjia Lu1, Pengfei Liu1

  • 1State Key Laboratory of Biobased Material and Green Papermaking, School of Food Science and Engineering, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China.

Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
|September 10, 2023
PubMed
Summary
This summary is machine-generated.

Low molecular weight Lycium barbarum L. oligosaccharides (LBO) act as a prebiotic, improving gut microbiota and reducing liver fibrosis in mice. These findings highlight LBO

Keywords:
Fecal metabolomeFecal microbiomeLiver fibrosisLycium barbarum oligosaccharidesStructure

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Area of Science:

  • Nutritional Science
  • Microbiology
  • Hepatology

Background:

  • Lycium barbarum L. (LBO) are low molecular weight oligosaccharides with enhanced antioxidant and digestibility properties.
  • While globally consumed, the therapeutic potential of LBO for liver disease remains unexplored.
  • High molecular weight polysaccharides show lower efficacy compared to LBO.

Purpose of the Study:

  • To investigate the efficacy of LBO in treating liver fibrosis.
  • To explore the role of LBO in modulating the gut microbial ecosystem for liver health.

Main Methods:

  • LBO were prepared and characterized for their chemical structure.
  • Carbon tetrachloride (CCl4)-induced liver fibrosis in mice was treated with oral LBO administration.
  • Effects were assessed by analyzing gut microbiota, fecal metabolites, and physiological/biochemical markers.

Main Results:

  • LBO, a pyranose cyclic oligosaccharide, acts as a prebiotic, promoting beneficial gut bacteria (e.g., Bacillus, Tyzzerella).
  • LBO supplementation improved microbial metabolism, including carbohydrate and vitamin metabolism, and entero-hepatic circulation.
  • LBO reduced inflammatory cytokines and hepatic hydroxyproline, enhanced mitochondrial function, and ameliorated liver fibrosis.

Conclusions:

  • LBO demonstrates significant potential as a prebiotic agent.
  • LBO effectively mitigates liver fibrosis by modulating the gut microbiota and improving host metabolism.
  • These findings support LBO as a novel therapeutic strategy for liver fibrosis.