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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Translational Regulation

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Translational regulation in prokaryotes ensures efficient protein synthesis by controlling ribosome access to mRNA. This regulation is mediated by secondary RNA structures, including translational riboswitches, RNA thermometers, and small RNAs (sRNAs), which respond to intracellular and environmental signals to modulate gene expression.Translational RiboswitchesRiboswitches in the leader region of mRNAs can regulate translation by altering the accessibility of the Shine-Dalgarno (SD) sequence,...
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Related Experiment Video

Updated: Jul 16, 2025

Assessing Mitochondrial Function in Sciatic Nerve by High-Resolution Respirometry
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Long Non-coding RNAs Influence Aging Process of Sciatic Nerves in SD Rats.

Rui Kuang1, Yi Zhang1, Guanggeng Wu1

  • 1Department of Plastic Surgery, the First Affiliated Hospital of Sun Yat-Sen University, No. 58 Zhongshan Road 2, Guangzhou 510080, China.

Combinatorial Chemistry & High Throughput Screening
|September 11, 2023
PubMed
Summary

Aging alters long non-coding RNAs (lncRNAs) in rat sciatic nerves, impacting lipid metabolism and extracellular matrix. Key genes like Hmgcr may be crucial for understanding nerve aging.

Keywords:
DNA.Long non-coding RNAsagingbioinformaticsperipheral nervestranscriptome

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Area of Science:

  • Neuroscience
  • Genomics
  • Molecular Biology

Background:

  • Aging significantly impacts peripheral nerve function.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in cellular processes, including aging.
  • Understanding lncRNA changes in the aging sciatic nerve (SN) is crucial for identifying mechanisms of age-related neuropathy.

Purpose of the Study:

  • To investigate the differential expression of lncRNAs in the sciatic nerve of Sprague Dawley (SD) rats during aging.
  • To identify key molecular pathways and potential regulatory networks involved in SN aging.

Main Methods:

  • Sciatic nerves were collected from young (1-month-old) and aged (24-month-old) SD rats.
  • High-throughput transcriptome sequencing was employed to identify differentially expressed lncRNAs (DElncRNAs).
  • Bioinformatics analyses, including Gene Ontology (GO) analysis, protein-protein interaction (PPI) network construction, and competing endogenous RNA (ceRNA) network analysis, were performed.

Main Results:

  • A total of 4079 DElncRNAs were identified between young and aged rats.
  • GO analysis revealed enrichment in lipid metabolism, extracellular matrix (ECM) remodeling, and vascularization pathways.
  • PPI networks highlighted genes such as Itgb2, Lox, Col11a1, Wnt5a, Kras (up-regulated targets) and Col1a1, Hmgcs1, Hmgcr (down-regulated targets).

Conclusions:

  • Lipid metabolism, angiogenesis, and ECM remodeling are implicated in sciatic nerve aging.
  • Specific lncRNAs and protein-coding genes, including Col3a1, Serpinh1, Hmgcr, and Fdps, are potential candidates for further investigation into nerve aging mechanisms.