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At the Crossroads of TNF α Signaling and Cancer
1Department of Biological Sciences, Sunandan Divatia School of Science, NMIMS (Deemed-to-be) University, Vile Parle (West), Mumbai 400056, India.
Current Molecular Pharmacology
|September 11, 2023
Summary
Tumor necrosis factor-alpha (TNFα) is a pro-inflammatory cytokine regulating cell death and proliferation. Understanding its complex signaling is crucial for cancer therapy and targeting inflammatory diseases.
Area of Science:
- Molecular Biology
- Immunology
- Oncology
Background:
- Tumor necrosis factor-alpha (TNFα) is a key pro-inflammatory cytokine.
- It activates intracellular signaling pathways (e.g., MAPK, Akt, NF-κB) regulating cellular processes.
- Dysregulated TNFα signaling is linked to inflammatory diseases, neurological disorders, and cancer.
Conclusions:
- TNFα signaling is a complex network with significant implications in cancer.
- Targeting TNFα pathways offers potential for novel anticancer strategies.
- Further research into TNFα's pleiotropic roles is vital for clinical applications.
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