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Updated: Jul 16, 2025
Analysis of Microglia and Monocyte-derived Macrophages from the Central Nervous System by Flow Cytometry
Published on: June 22, 2017
Brain perivascular macrophages: current understanding and future prospects
Wenjie Wen1,2,3, Jinping Cheng1,2,3, Yamei Tang1,2,3
1Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.
Brain perivascular macrophages play key roles in brain health and disease. Understanding these specialized immune cells offers new avenues for neuroprotection and treating neurological disorders.
Area of Science:
- Neuroimmunology
- Cerebrovascular Biology
- Cellular Biology
Background:
- Brain perivascular macrophages are specialized immune cells residing around cerebral blood vessels.
- Recent advancements reveal their roles in phagocytosis, antigen presentation, vascular integrity, and metabolism under normal conditions.
Conclusions:
- The precise mechanisms of perivascular macrophages require further investigation.
- Future research should focus on genetic mouse models and targeted therapeutic strategies for neuroprotection.
- This review offers an updated perspective on brain perivascular macrophages in CNS health and disease.
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