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A Rapid and Specific Microplate Assay for the Determination of Intra- and Extracellular Ascorbate in Cultured Cells
Published on: April 11, 2014
Ascorbic acid intake during pregnancy
Kristina Podolska1, Dana Mazankova1, Maria Goboova2
1Department of Applied Pharmacy, Faculty of Pharmacy, Masaryk University, 612 00 Brno, Czech Republic.
Insights
Maternal intake of vitamin C (ascorbic acid) during pregnancy is crucial for fetal development and may reduce childhood allergies. Deficiencies can impact brain development and immunity.
Area of Science:
- Pediatrics
- Nutrition Science
- Immunology
Background:
- Rising global incidence of childhood allergies presents a significant public health concern.
- Maternal antenatal diet and essential nutrient intake are implicated in fetal development and immune programming.
- Vitamin C (ascorbic acid) is vital, with even minor deficiencies potentially causing permanent developmental impairments.
Purpose of the Study:
- To review ascorbic acid status in maternal and fetal organs.
- To emphasize the role of vitamin C in fetal immunity.
- To explore the relationship between maternal diet and childhood allergic conditions.
Main Methods:
- Literature review focusing on vitamin C deficiency and its effects.
- Analysis of studies investigating the link between maternal fruit and vegetable intake and childhood allergies.
- Inclusion of other relevant review findings.
Main Results:
- Ascorbic acid deficiency affects both maternal and fetal organ health.
- Evidence suggests an inverse correlation between maternal consumption of fresh produce and the prevalence of childhood allergies.
- Vitamin C plays a critical role in developing fetal immunity.
Conclusions:
- Adequate maternal vitamin C intake is essential for fetal immune system development.
- Dietary interventions during pregnancy, rich in fruits and vegetables, may be a strategy to mitigate childhood allergies.
- Further research into maternal nutrition's impact on allergic disease prevention is warranted.
Abstract:
The continuing global increase in allergic conditions and diseases in children is now a serious public health and scientific issue. Amongst other concerns is the maternal antenatal diet as intake of essential nutrients. Even small deficits in essential vitamin C can permanently impair the developing brain for example. In this article, we first review ascorbic acid deficiency in different organs of both mother and foetus. However, major emphasis is on the importance of vitamin C in foetal immunity with studies showing an inverse relationship between maternal intake of fresh fruit and vegetables and allergic conditions in childhood, inter alia. Other review results are included.
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