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Related Experiment Video

Updated: Jul 16, 2025

Collection and Processing of Lymph Nodes from Large Animals for RNA Analysis: Preparing for Lymph Node Transcriptomic Studies of Large Animal Species
12:53

Collection and Processing of Lymph Nodes from Large Animals for RNA Analysis: Preparing for Lymph Node Transcriptomic Studies of Large Animal Species

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Evaluation of automated sample preparation system for lymph node sampling.

Jennifer D Duke1, Charles D Sturgis2, Christopher Hartley2

  • 1Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, MN, USA.

Journal of Thoracic Disease
|September 11, 2023
PubMed
Summary
This summary is machine-generated.

A new automated system for preparing lymph node biopsy slides shows comparable quality to standard methods. This automated approach for endobronchial ultrasound-guided transbronchial fine needle aspiration (EBUS-FNA) improves slide preparation efficiency.

Keywords:
Lung cancerbiopsybronchoscopypathologyrapid onset evaluation

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Area of Science:

  • Pulmonology
  • Oncology
  • Pathology

Background:

  • Endobronchial ultrasound-guided transbronchial fine needle aspiration (EBUS-FNA) is crucial for diagnosing non-small cell lung cancer and thoracic lymphadenopathy.
  • Current rapid on-site evaluation (ROSE) faces challenges with sample quality and lengthy procedure times.
  • Optimizing ROSE is essential for improving diagnostic workflows.

Purpose of the Study:

  • To assess the feasibility of a novel automated system for slide preparation.
  • To compare specimen quality of automated vs. standard slide preparation in EBUS-FNA.
  • To evaluate diagnostic adequacy and concordance of automated slides.

Main Methods:

  • A prospective, single-center pilot study involved patients undergoing EBUS.
  • Lymph node samples were divided for standard of care (SOC) and automated (instrument) slide preparation.
  • Pathologists evaluated slides based on nuclear/cytoplasmic quality, debris, staining, monolayer formation, and diagnostic assessment using a 1-3 scoring system.

Main Results:

  • Seventy-two samples from 60 patients were analyzed.
  • No significant difference in quality metrics between automated and SOC slides, except for improved monolayer formation with the automated system.
  • 96.8% diagnostic equivalency between automated and SOC slides, with one discordant case noted.

Conclusions:

  • Automated slide preparation yields adequate quality for adequacy assessment in EBUS-FNA.
  • The automated system demonstrates diagnostic concordance with conventional methods.
  • This technology shows promise for streamlining ROSE procedures.