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Related Experiment Video

Updated: Jul 16, 2025

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality
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Organoids as complex (bio)systems.

Tiago G Fernandes1,2

  • 1Department of Bioengineering and iBB-Institute for Bioengineering and Biosciences, Instituto Superior Técnico, Universidade de Lisboa, Lisbon, Portugal.

Frontiers in Cell and Developmental Biology
|September 11, 2023
PubMed
Summary
This summary is machine-generated.

Organoids, complex biological systems, are better understood using complex systems theory. This approach reveals insights into their function, disease, and potential therapeutic applications.

Keywords:
complex systemsdisease modelingorganoidsstem cellssystems biology

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Area of Science:

  • * Biological Systems and Developmental Biology
  • * Biotechnology and Bioengineering
  • * Computational Biology and Systems Biology

Background:

  • * Organoids are three-dimensional stem cell-derived structures mimicking organ function.
  • * They serve as valuable models for studying complex biological systems.
  • * Understanding organoid behavior is crucial for disease modeling and research.

Purpose of the Study:

  • * To explore the application of complex systems theory to organoid research.
  • * To identify and analyze common design principles in complex systems and their manifestation in organoids.
  • * To enhance understanding of organoid physiology, disease mechanisms, and therapeutic potential.

Main Methods:

  • * Review of complex systems theory principles.
  • * Analysis of how these principles apply to organoid structure and function.
  • * Comparative study across natural, technological, and social complex systems.

Main Results:

  • * Common design principles in complex systems are identifiable within organoids.
  • * These principles offer a framework for characterizing organoid behavior.
  • * The complex systems approach provides insights into normal function and disease alterations.

Conclusions:

  • * Viewing organoids through the lens of complex systems theory offers novel perspectives.
  • * This framework can illuminate normal physiological processes and disease pathogenesis.
  • * It may lead to new research avenues and therapeutic strategies for human health.