Related Experiment Video

Updated: Jul 16, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
08:41

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2

Published on: November 5, 2021

2.8K

Current state-of-the-art and potential future therapeutic drugs against COVID-19

Ailong Sha1,2, Yi Liu2, Haiyan Hao3

  • 1School of Teacher Education, Chongqing Three Gorges University, Chongqing, China.

Frontiers in Cell and Developmental Biology
|September 11, 2023
PubMed

Insights

This review analyzes 26 drugs for treating COVID-19, evaluating their effectiveness and safety in animal models. Five promising antiviral therapies are identified for further clinical trials.

Area of Science:

  • Virology
  • Pharmacology
  • Infectious Diseases

Background:

  • The COVID-19 pandemic necessitates urgent development of effective therapeutic drugs.
  • Animal models are crucial for assessing drug efficacy and toxicity before human clinical trials.
  • Understanding SARS-CoV-2 mechanisms, including S protein entry and viral replication involving RdRp and M protein, is key to drug discovery.

Purpose of the Study:

  • To review and analyze 26 drugs targeting SARS-CoV-2.
  • To evaluate the efficacy and safety profiles of these drugs in various animal models.
  • To identify the most promising drug candidates for advancing to clinical trials.

Main Methods:

  • Systematic review and analysis of existing literature on 26 anti-SARS-CoV-2 drugs.
  • Assessment of drug mechanisms of action against SARS-CoV-2.
  • Evaluation of drug effectiveness and toxicity data from preclinical animal studies.

Main Results:

  • Detailed analysis of 26 antiviral agents targeting different stages of the SARS-CoV-2 lifecycle.
  • Comparative assessment of drug performance across diverse animal models.
  • Identification of five drug candidates demonstrating favorable efficacy and safety profiles.

Conclusions:

  • Five drugs show significant promise for treating COVID-19 and warrant progression to clinical trials.
  • Preclinical data from animal models provides a critical foundation for selecting effective and safe therapeutic agents.
  • This review offers valuable insights for guiding future research and development of anti-SARS-CoV-2 therapies.
Keywords:
animal modelanti-SARS-CoV-2 drugscreeningviral loadviral titer

More Related Videos

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds09:29

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

30.3K
Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors10:29

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

1.2K

Related Concept Videos

Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
481
Drugs Used in Upper Respiratory Disorders: Overview01:16

Drugs Used in Upper Respiratory Disorders: Overview

Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
286
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
68
Principles of Drug Action01:24

Principles of Drug Action

Drugs are chemical substances that modify biological responses by interacting with macromolecular targets such as receptors, ion channels, transporters, and enzymes. Pharmacodynamics describes the course of action of drugs leading to the physiological effect at a specific site in the body.
Drugs can be agonists or antagonists. Like the endogenous ligands, agonists always bind and activate the target to produce a cellular response. Agonist binding induces a conformational change which in turn...
6.1K
Heart Failure Drugs: Inotropic Agents01:26

Heart Failure Drugs: Inotropic Agents

Positive inotropic agents are commonly used as the first line of treatment for heart failure. One such agent is digoxin, derived from the genus Digitalis, which has been known for centuries but effectively utilized since 1785. However, these cardiac glycosides can have potentially toxic effects due to their mechanism of action, which involves inhibiting Na+/K+-ATPase and increasing contractility. Digoxin is absorbed orally and distributed in various tissues, including the CNS. It has a long...
617
Drug Classes and Categories01:25

Drug Classes and Categories

Drugs can be classified according to their chemical composition or their intended therapeutic application. For instance, anti-infective agents that possess the ability to eliminate pathogens or suppress their growth and reproduction can be grouped based on the organisms they target or their chemical structure. Furthermore, drugs can be divided into prescription, nonprescription, or controlled substances. Prescription medications, such as antibiotics, require oversight from a licensed healthcare...
2.0K