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Experimental Model of Ligature-Induced Peri-Implantitis in Mice
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Association between peri-implantitis and systemic inflammation: a systematic review
Yumeng Yan1, Marco Orlandi1, Jeanie Suvan1
1Periodontology Unit, University College London (UCL) Eastman Dental Institute, University College London (UCL), London, United Kingdom.
Frontiers in Immunology
|September 11, 2023
Summary
Peri-implantitis is linked to increased systemic inflammation, with higher levels of C-reactive protein (CRP) and interleukin-6 (IL-6) observed. This systematic review confirms the association between peri-implantitis and inflammatory markers.
Area of Science:
- Oral Health
- Inflammatory Diseases
- Systemic Health
Background:
- Peri-implantitis shares clinical and radiographic similarities with periodontitis.
- While periodontitis is known to elevate systemic inflammatory mediators, this link is less clear for peri-implantitis.
Purpose of the Study:
- To systematically review and appraise existing evidence on the association between peri-implantitis and systemic inflammation.
Main Methods:
- A comprehensive systematic review adhering to PRISMA guidelines was conducted.
- Searches included eight electronic databases, clinical trial registries, and gray literature up to February 2023.
- Eleven human studies (RCTs, cohort, case-control, cross-sectional) were included in quantitative analyses.
Main Results:
- A consistent association between peri-implantitis and systemic inflammation was found across 11 studies.
- Patients with peri-implantitis showed significantly higher serum C-reactive protein (CRP), interleukin-6 (IL-6), and white blood cell counts.
- Specific findings included SMD of 4.68 for CRP and WMD of 6.27 pg/mL for IL-6.
Conclusions:
- Peri-implantitis is associated with elevated systemic inflammation markers, including CRP, IL-6, and white blood cell counts.
- Further research is warranted to elucidate the precise nature of this relationship.
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