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Serum Protein Profiling Reveals a Decrease in Apolipoprotein A-IV During a Clinical Depressive Mood State.

Sora Mun1, Seungyeon Lee2, Yeeun Yun3

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Journal of Inflammation Research
|September 11, 2023
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Researchers identified novel biomarkers for depression. Lower levels of apolipoprotein A-IV and fibronectin in serum indicate a current depressive episode, potentially aiding in objective diagnosis.

Keywords:
biomarkersdepressioninflammationliquid chromatography–tandem mass spectrometryneuroinflammationserum proteomics

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Area of Science:

  • Biochemistry
  • Neuroscience
  • Psychiatry

Background:

  • Depressive mood is a significant psychiatric condition impacting daily life.
  • Objective evaluation of psychiatric symptoms is challenging compared to physical symptoms.

Purpose of the Study:

  • To discover serum protein biomarkers reflecting metabolic changes in clinical depressive mood.
  • To identify objective indicators for diagnosing depression.

Main Methods:

  • Serum protein profiling using liquid chromatography-tandem mass spectrometry.
  • Analysis of participants without current depressive episodes (healthy and remission groups).
  • Verification of candidate biomarkers via multiple reaction monitoring analysis.

Main Results:

  • Apolipoprotein A-IV levels were significantly lower in individuals with current depression compared to healthy and remission groups.
  • Fibronectin levels were lower in individuals with current depression compared to healthy controls, but not remission groups.

Conclusions:

  • Apolipoprotein A-IV-mediated inflammation may play a role in clinical depression, potentially through neurological changes.
  • Apolipoprotein A-IV and fibronectin show potential as novel biomarkers for detecting current depressive episodes.