D-DI/PLT can be a prognostic indicator for sepsis

Area of Science:

• Critical Care Medicine
• Hematology
• Biochemistry

Background:

• Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection.
• Early identification of prognostic indicators is crucial for improving sepsis patient outcomes.
• Existing biomarkers and scoring systems have limitations in predicting sepsis prognosis.

Purpose of the Study:

• To identify key indicators affecting early sepsis patient outcomes.
• To evaluate the prognostic efficacy of identified indicators in sepsis.

Main Methods:

• Clinical data from 201 sepsis patients were analyzed.
• Patients were grouped by 28-day survival or fatality.
• Independent risk factors were identified using risk factor analysis and ROC curves.

Main Results:

• D-dimer (D-DI), SOFA score, platelet (PLT), INR, and the D-DI/PLT ratio were significant indicators.
• The D-DI/PLT ratio demonstrated high prognostic efficacy (AUC = 93.9).
• High D-DI/PLT, D-DI, SOFA, and low PLT were associated with decreased 28-day survival.

Conclusions:

• The D-DI/PLT ratio is a significant independent risk factor for poor sepsis prognosis.
• D-DI/PLT serves as a valuable clinical predictor for sepsis patient outcomes.
• This ratio can aid in early risk stratification and management of sepsis.