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A Mouse Model of Mechanotransduction-driven, Human-like Hypertrophic Scarring
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Osteopathic Approach for Keloids and Hypertrophic Scars
Bruno Bordoni1, Allan R Escher2, Gregory T Girgenti3
1Physical Medicine and Rehabilitation, Foundation Don Carlo Gnocchi, Milan, ITA.
Cureus
|September 11, 2023
Summary
Manual medicine may help manage pathological scars by addressing skin
Area of Science:
- Dermatology
- Regenerative Medicine
- Biomedical Engineering
Background:
- Skin is a complex, mechano-biologically active organ.
- Skin lesions trigger sensory, morphological, and functional alterations.
- Scar tissue formation follows distinct biological phases after injury.
Purpose of the Study:
- To review skin remodeling after injury.
- To evaluate the utility of manual medicine in scar management.
- To compare manual approaches with current literature on cicatricial processes.
Main Methods:
- Literature review of skin healing and scar formation.
- Analysis of manual medicine techniques for scar treatment.
- Comparison of manual approaches with established scientific understanding of scar healing.
Main Results:
- Some healing processes result in pathological scars causing pain, itching, and functional limitations.
- Current treatments lack a gold standard for diverse scar types and symptoms.
- Manual medicine involves direct manual approaches to injury sites.
Conclusions:
- Pathological scars present significant challenges in treatment.
- Existing manual medicine concepts may be based on erroneous ideas about scar healing.
- A gentle manual approach is recommended for pathological scar adaptations.

