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Glycopyrrolate-induced polyuria: An unexpected side effect.

Sunil Kumar Behera1, Abhishek Agarwal1, Alok Singh2

  • 1Department of General Medicine, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.

Journal of Neurosciences in Rural Practice
|September 11, 2023
PubMed
Summary
This summary is machine-generated.

Polyuria, excessive urine output, can be caused by medications. This case study highlights a rare association between glycopyrrolate and polyuria in a patient with Guillain-Barre Syndrome.

Keywords:
GlycopyrrolateGuillain–barre syndromePolyuria

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Area of Science:

  • Nephrology
  • Neurology
  • Clinical Pharmacology

Background:

  • Polyuria is defined as urine output exceeding 3 liters per day in adults.
  • It is typically caused by excessive water and solute diuresis.
  • Common hospital-induced causes include mannitol and diuretics.

Observation:

  • A case of Guillain-Barre Syndrome (GBS) was admitted to the hospital.
  • The patient developed significant polyuria during their hospital stay.
  • This polyuria was found to be associated with the administration of glycopyrrolate.

Findings:

  • This report describes a novel association between glycopyrrolate and polyuria.
  • To the authors' knowledge, no prior cases linking glycopyrrolate to polyuria have been documented.
  • The polyuria in this GBS patient was secondary to glycopyrrolate treatment.

Implications:

  • This finding suggests glycopyrrolate as a potential, previously unrecognized cause of polyuria.
  • Clinicians should consider glycopyrrolate when evaluating patients with unexplained polyuria, especially those with GBS.
  • Further research is warranted to understand the mechanism of glycopyrrolate-induced polyuria.