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Harnessing the Immune System: An Effective Way to Manage Diffuse Large B-Cell Lymphoma.
Nathan Visweshwar1, Juan Felipe Rico2, Robert Killeen3
1Department of Hematology, University of South Florida, Tampa, FL, USA.
Journal of Hematology
|September 11, 2023
Summary
Immunotherapy, including rituximab and CAR T-cell therapy, is transforming diffuse large B-cell lymphoma (DLBCL) treatment. Novel agents offer hope against refractory DLBCL, though challenges remain.
Area of Science:
- Hematology
- Immunology
- Oncology
Background:
- Diffuse large B-cell lymphoma (DLBCL) is a complex blood cancer influenced by the tumor microenvironment.
- Immunological factors are central to DLBCL's behavior and treatment strategies.
Purpose of the Study:
- To review the evolution and impact of immunological agents in DLBCL management.
- To discuss emerging immunotherapies for relapsed/refractory DLBCL.
Main Methods:
- Literature search of Medline, Embase, Cochrane databases, and clinical guidelines.
- Inclusion of studies from March 2010 to October 2022 focusing on DLBCL immunotherapies.
Main Results:
- Rituximab marked a significant advancement in DLBCL treatment.
- Novel immunotherapies, including CAR T-cell therapy, are reshaping care for relapsed/refractory cases.
Conclusions:
- Immunological approaches are the cornerstone of modern DLBCL therapy.
- Despite progress, overcoming resistance and refractory states in DLBCL remains a critical challenge.
- Future DLBCL treatment will be heavily influenced by advancing immunological agents.
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