Value of T lymphocyte subset detection in cervical intraepithelial neoplasia

This study aimed to explore the value of T lymphocyte subset detection in cervical intraepithelial neoplasia (CIN).

In this retrospective analysis, T lymphocyte subsets in 186 CIN patients were detected. Venous blood T lymphocyte subsets were analyzed in patients with different CIN grades, and Spearman correlation analysis was conducted between CIN grade and T lymphocyte subsets.

(1) There were significant differences in the CD3⁺, CD4⁺, CD8⁺, and CD4⁺/CD8⁺ levels before and 1, 2, and 3 months after treatment (P<0.05). Furthermore, significant differences were found in CD3⁺, CD4⁺, CD8⁺, and CD4⁺/CD8⁺ between every pair of time points (P<0.05). (2) Comparison of human papillomavirus distribution in patients with different CIN grades showed P<0.05. (3) The level of T lymphocyte subsets in the venous blood of patients with different CIN grades was compared, and significant differences were found, P<0.05. Higher CIN grade was associated with lower levels of CD3⁺, CD4⁺ and CD4⁺/CD8⁺, as well as higher level of CD8⁺. (4) Spearman analysis showed that CIN grade was negatively correlated with the levels of CD3⁺, CD4⁺, and CD4⁺/CD8⁺ (P<0.05) and positively correlated with the level of CD8⁺ (P<0.05).

The levels of T lymphocyte subsets were found to be closely associated with the severity of CIN. Therefore, the detection of T lymphocyte subsets in venous blood could be a valuable clinical tool for predicting the presence and degree of CIN.