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Updated: Jul 16, 2025

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
miR-182 promotes cervical cancer progression via activating the Wnt/β-catenin axis
Fei Gao1, Jilai Yin1, Yongcun Wang2
1The First Affiliated Hospital of Hainan Medical College Haikou, Hainan, China.
Abstract:
Cervical cancer (CC) is among the leading causes of cancer-associated mortality in women worldwide; yet the molecular regulators involved in its progression are unclear. This study found that miR-182 was overexpressed in CC tissues when compared with adjacent normal tissues. Moreover, it found that miR-182 expression was significantly positively correlated with distant metastasis in patients with CC. Interestingly, in vitro experiments showed that overexpression and inhibition of miR-182 promoted and suppressed the growth of CC cells, respectively. The tumor-promoting effects of miR-182 on CC progression were achieved via the Wnt/β-catenin axis and its downstream genes. Thus, this study revealed the potential of miR-182/β-catenin as an effective new target for CC treatment.
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