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Related Concept Videos

Hair Cells01:22

Hair Cells

40.7K
Hair cells are the sensory receptors of the auditory system—they transduce mechanical sound waves into electrical energy that the nervous system can understand. Hair cells are located in the organ of Corti within the cochlea of the inner ear, between the basilar and tectorial membranes. The actual sensory receptors are called inner hair cells. The outer hair cells serve other functions, such as sound amplification in the cochlea, and are not discussed in detail here.
40.7K
The Cochlea01:13

The Cochlea

45.2K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
45.2K

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Related Experiment Video

Updated: Jul 16, 2025

Whole Neonatal Cochlear Explants as an In vitro Model
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Large-scale annotated dataset for cochlear hair cell detection and classification.

Christopher J Buswinka1,2,3, David B Rosenberg1, Rubina G Simikyan1

  • 1Eaton Peabody Laboratories, Mass Eye and Ear, Boston, MA, 02114, USA.

Biorxiv : the Preprint Server for Biology
|September 11, 2023
PubMed
Summary
This summary is machine-generated.

Researchers created a large, annotated dataset of cochlear hair cells from multiple species to train machine learning models for automated hearing research. This resource aids in quantifying hair cells for better understanding of hearing conditions and treatments.

Keywords:
annotationcochleadetectionhair cellsinner hair cellmachine-learning-ready dataouter hair cell

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Area of Science:

  • Oto-neuroscience
  • Bioinformatics
  • Medical Imaging

Background:

  • Hearing relies on cochlear hair cells within the organ of Corti.
  • These cells are terminally differentiated and do not regenerate, making their quantification crucial for hearing research.
  • Manual quantification of numerous hair cells in cochlear samples is impractical, necessitating automated methods.

Approach:

  • Developed a large, annotated dataset of cochlear hair cells (>90,000 cells) from mouse, human, pig, and guinea pig.
  • Data includes samples under normal conditions and following ototoxic drug exposure (in vivo and in vitro).
  • Utilized various fluorescence microscopy techniques and manual annotation of inner and outer hair cells.

Key Points:

  • The dataset features diverse species, imaging techniques, and experimental conditions.
  • Provides suggested usage parameters and a detailed annotation procedure.
  • Facilitates the development of generalizable cochlear hair cell detection models.

Conclusions:

  • This curated dataset supports the advancement of automated hair cell quantification in hearing research.
  • Enables the development of tools for more accurate and efficient analysis of cochlear imaging data.
  • Aims to empower the hearing research community with robust data for tool development.