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Related Experiment Video

Updated: Jul 16, 2025

A System for Tracking the Dynamics of Social Preference Behavior in Small Rodents

A System for Tracking the Dynamics of Social Preference Behavior in Small Rodents

Published on: November 21, 2019

Space wandering in the rodent default mode network.

Trang-Anh Estelle Nghiem¹, Byeongwook Lee¹, Tzu-Hao Harry Chao^2,3,4

¹Department of Psychiatry & Behavioral Sciences, Stanford University.

Biorxiv : the Preprint Server for Biology

|September 11, 2023

Summary

This summary is machine-generated.

The default mode network (DMN) actively encodes spatial exploration in freely moving rats, challenging its "task-negative" label. This network shows dynamic engagement with real-world behaviors.

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Area of Science:

Neuroscience
Systems Neuroscience
Cognitive Neuroscience

Background:

The default mode network (DMN) is typically suppressed during cognitive tasks, but its role in naturalistic behaviors is poorly understood.
Previous research is limited by the restrictive environment of MRI scanners, hindering studies of unconstrained behavior.

Approach:

Used multisite GCaMP fiber photometry and videography in awake, freely exploring rats.
Examined neural dynamics in core DMN nodes (retrosplenial cortex, cingulate cortex, prelimbic cortex) and the anterior insula (salience network).
Correlated neural activity with spatial exploration kinematics.

Key Points:

DMN nodes exhibited hierarchical functional organization during exploration, with stronger internal coupling than with the anterior insula.
DMN nodes encoded spatial exploration kinematics, including linear and angular velocity.
Higher linear velocity correlated with enhanced DMN activity, increased DMN synchronization, and greater DMN-anterior insula anticorrelation.

Conclusions:

The DMN is dynamically involved in encoding spatial exploration in ecologically valid contexts.
Findings challenge the view of the DMN as solely a "task-negative" network disengaged from external stimuli.
Investigating brain networks in naturalistic settings is crucial for understanding their function.