Related Experiment Video
Updated: Jul 16, 2025
The Synergistic Effect of Visible Light and Gentamycin on Pseudomona aeruginosa Microorganisms
Published on: July 2, 2013
Formulation of Benzoyl Peroxide Microsponge-based Transdermal Gel for Acne Infection and Its Evaluation
Samali S Raut1, Neha R Singh1, Bhushan R Rane1
1Department of Pharmaceutics, Shri D.D. Vispute College of Pharmacy and Research Center, New Panvel, Maharashtra, 410206, India.
Background:
Benzoyl peroxide is a peroxide with antibacterial, irritating, keratolytic, comedolytic, and anti-inflammatory properties. When benzoyl peroxide is applied topically, it breaks down and releases oxygen, which kills the germs of Propionibacterium acnes. Benzoyl peroxide's irritating impact causes an increase in epithelial cell turnover, which causes the skin to peel and aids in the healing of comedones. Treatment for acne vulgaris involves the use of benzoyl peroxide.
Objective:
The research is aimed at studying the formulation of Microsponge gel preparation of benzoyl peroxide by using Carbopol 934 as a gelling agent and evaluation of microsponge gel formulation for its physicochemical properties.
Methods:
Microsponges of anti-acne agent benzoyl peroxide drug were prepared by quasi-emulsion method, and in-vitro drug release using a suitable membrane model using a simple diffusion cell.
Results And Discussion:
Prior to drying, the microsponge was filtered and rinsed using distilled water. Formulation containing benzoyl peroxide and Eudragit RS100 with a ratio of 1:4 showed a high 87.5% drug content and 78.20 % yield. The drug content of the microsponge gel was found to be 84%. Microbiological study on S. aureus was conducted by the cylinder cup method and found good results. The invitro diffusion of microsponge formulations was sustained for 8 hours. The drug release rate for Eudragit RS-100 was reported to be 88.87% after 8 hours based on the polymer: drug ratio (4:1).
Conclusion:
The quasi-emulsion solvent diffusion method was used to successfully prepare benzoyl peroxide microsponges using Eudragit RS100, Ethyl Cellulose, and HPMC K4M as polymers. The formulations with the highest medication concentration were made with the porous polymer Eudragit RS100.
Insights
This study developed benzoyl peroxide microsponges for acne treatment. The optimized formulation demonstrated sustained drug release and antibacterial properties, offering a promising approach for managing acne vulgaris.
Area of Science:
- Pharmaceutical Sciences
- Dermatology
- Materials Science
Background:
- Benzoyl peroxide is a key therapeutic agent for acne vulgaris, known for its antibacterial, keratolytic, and anti-inflammatory properties.
- It effectively combats Propionibacterium acnes by releasing oxygen and promotes healing by increasing epithelial cell turnover.
Purpose of the Study:
- To formulate and evaluate benzoyl peroxide microsponges using Carbopol 934 as a gelling agent.
- To assess the physicochemical properties and in-vitro drug release of the benzoyl peroxide microsponge gel preparation.
Main Methods:
- Benzoyl peroxide microsponges were prepared using the quasi-emulsion solvent diffusion method with polymers like Eudragit RS100.
- In-vitro drug release studies were conducted using a diffusion cell, and microbiological efficacy was assessed against S. aureus.
Main Results:
- A formulation with benzoyl peroxide and Eudragit RS100 (1:4 ratio) exhibited high drug content (87.5%) and yield (78.20%).
- The microsponge gel showed 84% drug content, sustained drug release for 8 hours with Eudragit RS-100 achieving 88.87% release.
- Positive results were observed in the microbiological study against S. aureus.
Conclusions:
- Benzoyl peroxide microsponges were successfully prepared using the quasi-emulsion solvent diffusion method with Eudragit RS100, Ethyl Cellulose, and HPMC K4M.
- Formulations utilizing the porous polymer Eudragit RS100 demonstrated the highest drug concentration, indicating its suitability for enhanced anti-acne delivery.
