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Updated: Jul 16, 2025

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
Published on: January 16, 2019
Genetics can inform causation, but the concepts and language we use matters
Sara A Hart1,2, Christopher Schatschneider1,2
1Department of Psychology, Florida State University, Tallahassee, FL, USA sahart@fsu.edu www.idcdlab.com schatschneider@psy.fsu.edu.
Abstract:
Madole & Harden describe how genetics can be used in a causal framework. We agree with many of their opinions but argue that comparing within-family designs to experiments is unnecessary and that the proposed influence of genetics on behavior can be better described as inus conditions.
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