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Updated: Jul 16, 2025

Gene-targeted Random Mutagenesis to Select Heterochromatin-destabilizing Proteasome Mutants in Fission Yeast
Published on: May 15, 2018
The providential randomisation of genotypes
Jean-Baptiste Pingault1, Pasco Fearon1, Essi Viding1
1Department of Clinical, Educational and Health Psychology, University College London, London, UK j.pingault@ucl.ac.uk www.jeanbaptistepingault.com p.fearon@ucl.ac.uk https://www.cfr.cam.ac.uk/staff/professor-pasco-fearon e.viding@ucl.ac.uk https://www.ucl.ac.uk/pals/people/essi-viding.
Abstract:
When building causal knowledge in behavioural genetics, the natural randomisation of genotypes at conception (approximately analogous to the artificial randomisation occurring in randomised controlled trials) facilitates the discovery of genetic causes. More importantly, the randomisation of genetic material within families also enables a better identification of (environmental) risk factors and aetiological pathways to diseases and behaviours.
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