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Updated: Jul 16, 2025

Large-Scale Multi-Omics Genome-Wide Association Studies Mo-GWAS: Guidelines for Sample Preparation and Normalization
Published on: July 27, 2021
Genome-wide association study and the randomized controlled trial: A false equivalence
1School of Natural and Social Sciences, Purchase College, State University of New York, Purchase, NY, USA paul.siegel@purchase.edu https://www.purchase.edu/live/profiles/671-paul-siegel.
Abstract:
Madole & Harden's assertion that the effects derived from within-family genome-wide association studies (GWASs) and from randomized controlled trials (RCTs) are equivalent is misleading. GWASs are substantially more "non-unitary, non-uniform, and non-explanatory" than RCTs. While the within-family GWAS bring us closer to identifying genetic causes, whether it will change behavioral genetics into a causal science is an open question.
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