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Published on: August 15, 2019
Social scientists would do well to steer clear of polygenic scores
David Curtis1,2
1UCL Genetics Institute, University College London, London, UK d.curtis@ucl.ac.uk; http://www.davecurtis.net/dcurtis.html.
Abstract:
The problems with polygenic scores (PGSs) have been understated. The fact that they are ancestry-specific means that biases related to sociodemographic factors would be impossible to avoid. Additionally, the requirement to obtain DNA would have profound impacts on study design and required resources, as well as likely introducing recruitment bias. PGSs are unhelpful for social science research.
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