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Polygenic scores for social science: Clarification, consensus, and controversy
1Department of Criminal Justice & Criminology, Center for Research on Interpersonal Violence (CRIV), Georgia State University, Atlanta, GA, USA cburt@gsu.edu; www.callieburt.org.
The Behavioral and Brain Sciences
|September 11, 2023
Summary
Polygenic scores (PGSs) show potential for social science but require careful interpretation. This work clarifies arguments, addresses competing views, and emphasizes scientific skepticism for responsible application.
Area of Science:
- Social science research
- Genetics
- Statistical modeling
Background:
- Polygenic scores (PGSs) are increasingly discussed for social science applications.
- Debates exist regarding their utility and interpretation in complex human behaviors.
Purpose of the Study:
- To clarify arguments surrounding the utility of polygenic scores (PGSs) in social science.
- To highlight scientific consensus and address competing viewpoints.
- To suggest expansions and alternative approaches for PGS research.
Main Methods:
- Literature review and synthesis of existing arguments.
- Conceptual analysis of polygenic score applications.
- Discussion of methodological and ethical considerations.
Main Results:
- Arguments for PGS utility in social science are presented and critically examined.
- Areas of consensus and disagreement regarding PGS application are identified.
- Potential expansions and alternative research strategies are proposed.
Conclusions:
- Reiteration of the need for caution in interpreting and applying PGSs in social science.
- Emphasis on maintaining appropriate scientific skepticism.
- Advocacy for rigorous methodology and responsible scientific discourse.
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