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Often wrong, sometimes useful: Including polygenic scores in social science research
1Center for Demography of Health and Aging, La Follette School of Public Affairs, University of Wisconsin-Madison, Madison, WI 53706, USA jason.fletcher@wisc.edu.
The Behavioral and Brain Sciences
|September 11, 2023
Summary
Polygenic scores (PGSs) are sometimes useful but often misused in social science research. This commentary navigates a balanced perspective between extreme views on their utility.
Area of Science:
- Social Science
- Genetics
- Psychology
Background:
- Polygenic scores (PGSs) are increasingly used in social science.
- Debate exists regarding the utility and interpretation of PGSs in this field.
Purpose of the Study:
- To establish a balanced perspective on the use of PGSs in social science.
- To address criticisms and overstatements concerning PGSs.
Main Methods:
- Commentary and critical review of current practices.
- Analysis of the utility and limitations of PGSs in social science research.
Main Results:
- Current application of PGSs in social science is frequently incorrect.
- Despite limitations, PGSs can offer occasional utility in specific social science contexts.
Conclusions:
- A nuanced approach is needed for integrating PGSs into social science.
- Avoidance of both dismissal and over-interpretation is crucial for responsible use.
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