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Induction of Drug-Induced, Autoimmune Hepatitis in BALB/c Mice for the Study of Its Pathogenic Mechanisms
Published on: May 29, 2020
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CD4+ T-cell subsets in autoimmune hepatitis: A review
Haoran Chen1, Zhongyu Han2, Yiyue Fan3
1Chengdu Xinhua Hospital, Chengdu, China.
Hepatology Communications
|September 11, 2023
Summary
Autoimmune hepatitis (AIH) involves immune system dysfunction. This review explores CD4+ T-cell subsets in AIH, highlighting their role in disease pathogenesis and potential as therapeutic targets.
Area of Science:
- Immunology
- Hepatology
- Autoimmunity
Background:
- Autoimmune hepatitis (AIH) is a chronic liver disease causing inflammation and potential liver failure.
- Current treatments like corticosteroids have side effects and relapse issues.
- AIH involves immune dysregulation, including T and B cell imbalances.
Conclusions:
- CD4+ T-cell subsets play a critical role in the immune pathology of AIH.
- Targeting specific CD4+ T-cell subsets offers promising therapeutic avenues for AIH treatment.
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