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Updated: Jul 16, 2025

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration
Published on: October 13, 2019
[I lead, follow me! How cells coordinate during collective migrations.]
1Unité de recherche en transport vésiculaire et signalisation cellulaire, Institut pour la recherche en immunologie et en cancérologie de l'université de Montréal (IRIC), Université de Montréal, Montréal, Québec H3C 3J7, Canada - Département de pathologie et biologie cellulaire, Faculté de médecine, Université de Montréal, Montréal, Québec H3C 3J7, Canada.
Abstract:
During development and wound healing, cells frequently move in a so-called "collective cell migration" process. The same type of migration is used by some cancer cells during metastasis formation. A powerful model to study collective cell migration is the border cell cluster in Drosophila as it allows the observation and manipulation of a collective cell migration in its normal environment. This review describes the molecular machinery used by the border cells to migrate directionally, focusing on the mechanisms used to detect and reacts to chemoattractants, and to organise the group in leader and follower cells.
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