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A Syngeneic Pancreatic Cancer Mouse Model to Study the Effects of Irreversible Electroporation
Published on: June 8, 2018
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New Developments in Image-Guided Percutaneous Irreversible Electroporation of Solid Tumors
Jung H Yun1, Adam Fang2, Fereshteh Khorshidi2
1Division of Vascular and Interventional Radiology, Jefferson Einstein Hospital, Philadelphia, PA, USA.
Current Oncology Reports
|September 11, 2023
Summary
Irreversible electroporation (IRE) is a minimally invasive ablation technique for solid tumors. Advancements in IRE technology improve its efficacy and safety, offering benefits over traditional methods, especially when combined with other therapies.
Area of Science:
- Oncology
- Medical Technology
- Surgical Innovation
Background:
- Minimally invasive image-guided percutaneous irreversible electroporation (IRE) is a non-thermal ablation technique for solid organ tumors.
- IRE is advantageous for ablating tumors near heat-sensitive structures like blood vessels and nerves, avoiding the heat sink effect.
Purpose of the Study:
- To review the applications, benefits, risks, and approaches of conventional irreversible electroporation (IRE).
- To highlight technological advancements and clinical applications of IRE.
Main Methods:
- Review of current literature on irreversible electroporation (IRE) techniques and outcomes.
- Analysis of technological developments, including H-FIRE, needle placement systems, and robotics.
Main Results:
- IRE is a safe and effective treatment for liver, pancreas, kidney, and prostate tumors, with advantages over other ablation methods.
- Technological advancements have enhanced IRE probe placement accuracy and system efficacy.
- IRE shows promise when combined with chemotherapy, immunomodulation, and immunotherapy.
Conclusions:
- Irreversible electroporation (IRE) is a valuable tool in solid tumor ablation, particularly with recent technological improvements.
- Further research into combination therapies involving IRE may enhance treatment outcomes.
