Related Experiment Video
Updated: Jul 16, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
Machine learning models for predicting pre-eclampsia: a systematic review protocol
Amene Ranjbar1, Elham Taeidi2, Vahid Mehrnoush2
1Fertility and Infertility Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Introduction:
Pre-eclampsia is one of the most serious clinical problems of pregnancy that contribute significantly to maternal mortality worldwide. This systematic review aims to identify and summarise the predictive factors of pre-eclampsia using machine learning models and evaluate the diagnostic accuracy of machine learning models in predicting pre-eclampsia.
Methods And Analysis:
This review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. This search strategy includes the search for published studies from inception to January 2023. Databases include the Cochrane Central Register, PubMed, EMBASE, ProQuest, Scopus and Google Scholar. Search terms include 'preeclampsia' AND 'artificial intelligence' OR 'machine learning' OR 'deep learning'. All studies that used machine learning-based analysis for predicting pre-eclampsia in pregnant women will be considered. Non-English articles and those that are unrelated to the topic will be excluded. PROBAST (Prediction model Risk Of Bias ASsessment Tool) will be used to assess the risk of bias and the applicability of each included study.
Ethics And Dissemination:
Ethical approval is not required, as our review will include published and publicly accessible data. Findings from this review will be disseminated via publication in a peer-review journal.
Prospero Registration Number:
This review is registered with PROSPERO (ID: CRD42023432415).
More Related Videos
Related Concept Videos
Mechanistic Models: Compartment Models in Individual and Population Analysis
Prediction Intervals
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y.

