Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Necrosis

Necrosis

Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become anucleated and die, but their...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Successful treatment of acute organophosphorus pesticide poisoning complicated by intestinal necrosis with exploratory laparotomy: a case report.

Open medicine (Warsaw, Poland)·2026

Same author

A Narrative Review of Stem Cell-Derived Exosomes for Diabetic Nephropathy.

Stem cells international·2026

Same author

Cyclosporine A protects against wasp venom-induced rhabdomyolysis in rats by inhibiting the CypD-mPTP pathway.

Toxicon : official journal of the International Society on Toxinology·2026

Same author

Guillain-Barré syndrome following <i>Escherichia coli</i> meningitis after cupping therapy: a case report.

Frontiers in immunology·2026

Same author

Postoperative foreign body retention following anal injury leading to a giant bladder stone: a case report.

BMC urology·2026

Same author

Extracorporeal membrane oxygenation for main airway rupture secondary to severe thoracic trauma: A case report.

Chinese journal of traumatology = Zhonghua chuang shang za zhi·2026

Search research articles

Related Experiment Video

Updated: Jul 22, 2026

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice

Published on: June 22, 2022

Targeting Ferroptosis Promotes Functional Recovery by Mitigating White Matter Injury Following Acute Carbon Monoxide

Shuhong Wang¹, Binyuan Xiong¹, Yin Tian²

¹Department of Emergency, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, China.

Molecular Neurobiology

|September 11, 2023

Summary

Acute carbon monoxide poisoning (ACMP) causes white matter injury (WMI) by inducing ferroptosis. Ferrostatin-1 treatment alleviated WMI and improved motor function by targeting iron and ROS accumulation.

Keywords:

Acute carbon monoxide poisoning Ferroptosis Ferrostatin-1 Nrf2/HO-1 signaling pathway White matter injury

More Related Videos

Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells

Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells

Published on: November 18, 2022

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

Related Experiment Videos

Last Updated: Jul 22, 2026

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice

A Model for Encephalomyosynangiosis Treatment after Middle Cerebral Artery Occlusion-Induced Stroke in Mice

Published on: June 22, 2022

Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells

Exploring the Two Herb Combination Strategy to Treat Injured PC12 Cells

Published on: November 18, 2022

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

Area of Science:

Neuroscience
Toxicology
Cellular Biology

Background:

Acute carbon monoxide poisoning (ACMP) survivors often develop white matter injury (WMI).
The precise mechanisms underlying ACMP-induced WMI are not fully understood.
Ferroptosis, a cell death pathway involving iron and reactive oxygen species (ROS), plays a role in oligodendrocyte damage and WMI progression.

Purpose of the Study:

To investigate the role of ferroptosis in ACMP-induced WMI.
To explore the therapeutic potential of targeting ferroptosis for mitigating WMI and motor deficits following ACMP.

Main Methods:

ACMP model induction in rodents.
Assessment of iron and ROS levels in brain tissue.
Evaluation of WMI and motor function recovery.
Administration of ferrostatin-1, an inhibitor of ferroptosis.
Analysis of the nuclear factor erythroid-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway.

Main Results:

ACMP led to increased iron and ROS accumulation, resulting in WMI and motor impairment.
Ferrostatin-1 treatment significantly reduced iron and ROS deposition, alleviating ferroptosis.
Ferrostatin-1 administration attenuated WMI and promoted recovery of motor function.
The Nrf2/HO-1 pathway was implicated in the ferroptosis-alleviating effects of ferrostatin-1.

Conclusions:

ACMP induces WMI and motor deficits through ferroptosis.
Targeting ferroptosis with agents like ferrostatin-1 is a promising therapeutic strategy for ACMP-induced WMI.
The Nrf2/HO-1 pathway is involved in the protective mechanisms against ACMP-induced ferroptosis.