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Monocyte to high-density lipoprotein ratio is associated with mortality in patients with coronary artery diseases
Gaiqin Pei1,2, Rui Liu1,2, Lu Wang1,2
1Department of Rehabilitation Medicine and Institute of Rehabilitation Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China.
Insights
The monocyte to high-density lipoprotein ratio (MHR) independently predicts mortality and complications in coronary artery disease (CAD) patients. This association is particularly strong in individuals with hypertension.
Area of Science:
- Cardiology
- Biomarkers
- Prognostic Indicators
Background:
- The prognostic significance of the monocyte to high-density lipoprotein ratio (MHR) in coronary artery disease (CAD) remains unclear.
- Existing research has not definitively established a link between MHR and patient outcomes in CAD.
Purpose of the Study:
- To investigate the association between the monocyte to high-density lipoprotein ratio (MHR) and prognosis in patients with coronary artery disease (CAD).
- To determine if MHR can predict all-cause mortality and in-hospital complications in CAD patients.
Main Methods:
- A cohort study including 5371 patients with CAD.
- Blood samples collected within 24 hours of admission.
- Multivariate Cox regression and ROC analysis to assess MHR's predictive value for mortality and complications.
Main Results:
- MHR was an independent predictor of all-cause mortality (HR 1.81), cardiovascular mortality (HR 1.69), and non-cardiovascular mortality (HR 2.04).
- The association between MHR and mortality was significant in hypertensive patients (P for interaction=0.003).
- Higher MHR levels correlated with increased risk of complications like infection, pneumonia, and gastrointestinal bleeding. MHR demonstrated superior prognostic value compared to individual monocyte and HDL levels.
Conclusions:
- The monocyte to high-density lipoprotein ratio (MHR) serves as an independent predictor for all-cause mortality and in-hospital complications in CAD patients.
- The prognostic value of MHR is especially pronounced in patients with co-existing hypertension.
- MHR offers a valuable prognostic tool in managing coronary artery disease patients.
Background:
Whether the monocyte to high-density lipoprotein ratio (MHR) is associated with the prognosis of coronary artery disease (CAD) is inconclusive.
Methods:
Patients with CAD were enrolled and their data were collected. Blood was sampled within 24 h after admission. Multivariate Cox regression analysis was performed to determine the relationship between the MHR and all-cause mortality as well as complications during hospitalization.
Results:
We included 5371 patients in our cohort study. Among them, 114 (2.12%) patients died in hospital. MHR was independently associated with all-cause mortality (hazard ratio [HR], 1.81; 95% confidence interval [CI] 1.35, 2.42), cardiovascular mortality (1.69; 1.17, 2.45) and non-cardiovascular mortality (2.04; 1.27, 3.28). This association was only observed in patients with hypertension (P for interaction = 0.003). Patients with higher MHR levels also have a higher risk of complications, including infection, pneumonia, electrolyte disturbance, gastrointestinal bleeding, multiple organ dysfunction syndrome, and disturbance of consciousness. The receiver operating characteristic (ROC) analysis showed that the MHR had higher prognostic values than monocytes and high-density lipoprotein.
Conclusion:
MHR was an independent predictor of all-cause mortality and in-hospital complications in patients with CAD, especially in patients with hypertension.
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