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A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis
Published on: August 12, 2020
Pediatric sepsis profile in a tertiary-care hospital in Indonesia: a 4-year retrospective study
Antonius Hocky Pudjiadi1, Nina Dwi Putri1, Stephanie Wijaya1
1Department of Child Health, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Insights
Pediatric sepsis in Indonesia has a high mortality rate of 76.1%, linked to septic shock and organ failure. Improved management and early recognition are crucial for better outcomes in children with sepsis.
Area of Science:
- Pediatrics
- Infectious Diseases
- Critical Care Medicine
Background:
- Pediatric sepsis remains a significant global health challenge.
- Effective management strategies are critical for improving survival rates in children.
- Understanding local factors influencing pediatric sepsis outcomes is essential.
Purpose of the Study:
- To investigate factors associated with mortality in pediatric sepsis patients.
- To evaluate the current management practices for pediatric sepsis in Indonesia.
- To identify areas for improvement in clinical care and hospital systems.
Main Methods:
- Retrospective study design.
- Inclusion of pediatric patients admitted with sepsis between January 2015 and December 2019.
- Data analysis focusing on mortality predictors and management interventions.
Main Results:
- A high mortality rate of 76.1% was observed in pediatric sepsis patients.
- Septic shock at triage, multiple organ failures, and ICU admission were significant mortality predictors.
- The timing of antibiotic administration did not significantly impact mortality outcomes.
- A substantial proportion of deaths (41.8%) occurred within the first 24 hours, primarily due to septic shock.
Conclusions:
- Pediatric sepsis management in the studied Indonesian hospital is currently inadequate.
- Enhancements in pre-hospital care, sepsis recognition, and critical care resource utilization are urgently needed.
- Development of hospital-specific sepsis protocols is recommended to reduce pediatric sepsis mortality.
Aim:
This study aimed to explore the factors contributing to mortality and its management among pediatric sepsis patients at a single center in Indonesia.
Method:
We conducted a retrospective study of children admitted due to sepsis from January 2015 to December 2019 in an Indonesian tertiary hospital.
Results:
The mortality rate of pediatric sepsis in our study was 76.1% among 176 records with outcome identified. Mortality was significantly associated with septic shock at triage, number of organ failure, intensive care unit admission, inotropic use, septic shock and severe sepsis during hospitalization. Timing of antibiotic use did not affect mortality. Death within the first 24 h occurred in 41.8% of subjects, mostly due to septic shock.
Conclusion:
This study illuminates the current state of pediatric sepsis management in our Indonesian hospital, revealing it as inadequate. Findings highlight the need for improved pre-hospital systems and sepsis recognition tools, and wider use of mechanical ventilators and advanced monitoring due to limited pediatric intensive care unit beds. Future research should focus on hospital-specific sepsis protocols to reduce pediatric sepsis mortality rates.
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