Related Experiment Video
Updated: Jun 12, 2026

Microfluidic Bioprinting for Engineering Vascularized Tissues and Organoids
Published on: August 11, 2017
Tailoring biomaterials for biomimetic organs-on-chips
Lingyu Sun1, Feika Bian1, Dongyu Xu1
1Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China. yjzhao@seu.edu.cn.
Biomaterials are crucial for developing advanced organs-on-chips, microfluidic devices mimicking human organ functions. This review highlights their role in creating better models for drug testing and understanding diseases.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Microfluidics
Background:
- Organs-on-chips are microfluidic devices that replicate organ functions.
- They offer advanced cell culture mimicking in vivo environments.
- Biomaterials are critical for organ-on-chip microstructure and function.
Purpose of the Study:
- To provide an overview of biomaterials used in organs-on-chips.
- To discuss biomaterial functions, fabrication, and applications.
- To highlight the potential of organs-on-chips as alternatives to animal testing.
Main Methods:
- Review of current literature on biomaterials for organs-on-chips.
- Analysis of biomaterial components, structures, and fabrication techniques.
- Examination of biomaterial functions and applications in organ-on-chip systems.
Main Results:
- Biomaterials significantly influence the performance of organs-on-chips.
- Various biomaterials are employed, affecting cell behavior and device functionality.
- Biomaterial-based organs-on-chips show promise as alternatives to animal models.
Conclusions:
- Biomaterials are essential for advancing organ-on-chip technology.
- Further research into biomaterials will enhance organ-on-chip capabilities.
- These advanced models have significant implications for pharmaceutical, chemical, and environmental testing.
Related Concept Videos
Transgenic Organisms
Mechanical Protein Functions
Mechanical Protein Function
Bioequivalence: Overview

